The most common types of liposomes are used in medical science to enhance and prolong the quality of life and health in patients suffering from long-term illnesses and diseases. Liposomes come from a Greek background with ‘Lipo’ meaning fat and ‘Soma’ meaning body. When you combine the two words and seek out its true meaning, it is easy to understand the work behind liposomes, and why the preparation process is vital in more ways than one. Through the study of the different types of liposomes, scientists have categorized liposomes into four main or major types; Multilamellar Vesicle or MLV, Small unilamellar liposome vesicle or (SUV), Large unilamellar vesicle or (LUV), and the Cochleate vesicle or (LUV).
Mulitlamellar vesicles are the simplest form of liposome. Liposomes in this class of lipids are utilized as organic, dried solvents with a combination of other lipids found in phosphatidyl glycerol, cholesterol and egg lecithin. Forms of chloroform and methanol are also found in this category of liposomes. Once the liposomes are prepared for production, a nitrogen (gas) steam is implemented to create a film from the mixture in the test tube. In the removal of any traces of organic residue, the lipid film is left to completely dry out in an isolated chamber for up to 6 hours.
Unilamellar vesicles are the main or perhaps the most popular of liposomes. Its unique structure allows trapped agents within a single internal compartment to be equally distributed. The methods used in the preparation of Unilamellar vesicles are freezing-thawing, injections of ethanol, polycarbonate filter extrusions, and ultrasonication.
Huge Unilamellar Vesicles
Giant or large Unilamellar Liposomes are prepared using distilled water, zwitterious or non-electrolyte. During the rehydration and/ or swelling process of the membrane sheets, one can expect an increase in the attraction of similar membranes. Researchers use strong physiological buffers in the demonstration of giant liposomes preparations through the use of several popular methods. These methods include using rapid electroformatoin and the osmotic shock technique. However, in the mechanical characterization microfludic, GUV was discovered as a new possibility.
Additional Information on The Different Types of Liposomes
Liposomes are important candidates researchers use in the preparation stage and the delivery of life- saving drugs. Researchers constantly expand their testing and treatment of using liposomes to the delivery treatment of various illnesses and diseases in several forms. For instance, in the treatment of cancer liposomes are used as anti-cancer agents. Other areas of treatment include bacterial infections which some antibiotic treatments are ineffective alone, but when administered with liposomes are quite effective in curing the infection. Overall, liposomes target infectious cells that ultimately affect healthy cells. It is through the preparation and delivery of liposomes agents that patients and researchers are able to benefit from the different types of liposomes and their uses.